Paraproteinemia and multiple myeloma
North South North West Statewide
The diagnosis of multiple myeloma requires the presence of a malignant plasma cell population (evidenced on bone marrow biopsy or plasmacytoma) AND demonstrable end-organ dysfunction
All referrals should comply to referral standards and include in particular:
- Relevant investigations, including previous results to assess temporal pattern
- Evidence of end-organ damage
- Renal function
- Xray of areas of suspicion
- Consider bone scan
To refer a patient with this condition, please see the Haematology clinic page for the full referral process and templates.
In the presence of a paraprotein, assessment for end-organ dysfunction (CRAB - see below) is critical in the diagnostic algorithm, and the following assessments should be enclosed:
- C – Hypercalcaemia
- R – Renal impairment (without other cause)
- A – Anaemia/other cytopenia (without other cause)
- B – Bone lesions (lytic lesions, pathological fracture, unexplained osteoporosis)
For more information please see the Tasmanian Health Pathways website.
Suspected spinal cord compression (pain and neurological symptoms) in a patient with known or suspected multiple myeloma.
Impending pathological fracture (radiologically identified) in a patient with known or suspected Multiple Myeloma
Significant hypercalcaemia >2.9 mmol/L
Red flags are clinical indicators of possible serious underlying conditions requiring further medical intervention. They may or may not indicate an emergency.
Proceed to Emergency Department (ED). Please contact ED Medical Officer in Charge:
LGH ED – Phone: (03) 6777 8302 Fax: (03) 6777 5201
MCH ED – Phone: 0409 867 492 Fax: (03) 6441 5923
NWRH ED – Phone: 0459 848 725 Fax: (03) 6464 1926
RHH ED - Phone: (03) 6166 6101 Fax: (03) 6173 0489 - Discuss with the on call Haematologist/Registrar via switch (03) 6166 8308
Urgent Referrals generally need to be seen in the next one to two weeks
Please discuss these with the Haematology Registrar/Haematologist on call via switchboard on 6166 8308
Triaged by medical staff and generally seen in the next six to eight weeks
Triaged by medical staff and given the next available appointment